Basicstero.ws - The Direct from Pharmacom Labs Store

Here you can get samples and free give away's at times
User avatar
Rick T
Posts: 135
Joined: Thu Jan 12, 2023 8:33 pm
Contact:

Re: Basicstero.ws - The Direct from Pharmacom Labs Store

Post by Rick T »

Farestos: Toremifene from Pharmacom Labs

Analytic testing performed by Janoshik.

RESULTS:
Image
1. Qualitative analysis: the sample contains the active ingredient: Toremifene Citrate.
2. Quantitative analysis showed the content of active ingredient: 19.92 mg.

Analysis conducted: 16 June 2023


Mobster
Posts: 544
Joined: Thu Mar 02, 2023 11:56 am

Re: Basicstero.ws - The Direct from Pharmacom Labs Store

Post by Mobster »

A proper CoA!
User avatar
Rick T
Posts: 135
Joined: Thu Jan 12, 2023 8:33 pm
Contact:

Re: Basicstero.ws - The Direct from Pharmacom Labs Store

Post by Rick T »

FARESTOS (Toremifene) – A More Modern SERM – is Available in the Basicstero Store.
Image

Toremifene (Fareston) is a more modern analogue of Tamoxifen and Clomid, which may be used to completely replace these older compounds’ useful properties.
Toremifene Citrate is a selective estrogen receptor modulator (SERM) derived from triphenylethylene. It was patented and approved in Europe in the mid 1990's to treat metastatic ER+ breast cancer in postmenopausal women.
Image
In bodybuilding toremifene citrate is used by men as a drug for post-cycle therapy (PCT) to counteract and/or block some of the effects of excessive estradiol in the body as a result of aromatization of various androgens used. In particular, toremifene is used to restore levels of endogenous testosterone in blood as well as to prevent the estrogen-related side effect of gynecomastia.
In its chemical structure toremifene is very similar to tamoxifen and clomiphene. However, toremifene is a new generation drug and has less toxic side effects than tamoxifen.
Toremifene dosage for a more effective boost in testosterone production should be in the range of up to 120mg per day. This dose can be maintained for a first week of PCT; then, 100mg/day for the second week of PCT; and, finally 60mg/day for the remaining 3 – 4 weeks of PCT. Of course, exact dosages should be determined individually based on blood work results.

This innovative SERM is currently available as a 50 count blister strip of 20 mg tablets at: basicstero.ws/pct/farestos-pills-20mg

Toremifene Information:
Image


Toremifene Description (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Toremifene citrate is an anti-estrogenic drug, specifically classified as a Selective Estrogen-Receptor Modulator (SERM) with mixed agonist and antagonist properties. It is a non-steroidal triphenylethylene derivative, similar in structure and action to both Nolvadex (tamoxifen citrate) and Clomid (clomiphene citrate). Toremifene citrate is used for the treatment of breast cancer in postmenopausal women with estrogen-receptor positive or estrogen-receptor unknown (unsure if the cancer is estrogen responsive) tumors. It works by attaching to the estrogen receptor in various tissues in a competitive manner, blocking endogenous estrogen from exerting biological activity. As an anti-estrogen in many tissues, male bodybuilders and athletes may use toremifene citrate to counter some of the side effects associated with the use of aromatizable or estrogenic anabolic/androgenic steroids. This may include gynecomastia, body fat gain, and increased water retention.

The triphenylethylene compounds (toremifene citrate, tamoxifen citrate, clomiphene citrate) tend to be somewhat intrinsically estrogenic in the liver. This means that while they can block estrogenic activity in some areas of the body, they can actually act as estrogens in this other key area. Estrogenic action in the liver is important in the regulation of serum cholesterol (it tends to support HDL synthesis and LDL reductions). Since steroid-using bodybuilders are already dealing with the negative cardiovascular effects of these drugs, compounding the issue with aromatase inhibitors (which will lower total serum estrogen levels) may not always be the best option. Using a drug that blocks gynecomastia, for example, while at the same time supporting improved cholesterol values, might be much more ideal. In terms of which triphenylethylene agent is most effective in this regard, evidence suggests that the positive lipid altering benefits of toremifene are significantly stronger than those of tamoxifen, a drug normally favored for this purpose. Toremifene citrate may, therefore, be the preferred antiestrogen among those concerned about their lipid profiles.

History (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Toremifene citrate was approved by the FDA as a prescription drug in 1997. It is sold in the U.S. under the Fareston brand name, which is made by GTx, Inc. Fareston is also available in over two dozen other countries including Australia, Austria, Belgium, Czech Republic, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Mexico, Netherlands, New Zealand, Portugal, Russia, South Africa, Spain, Sweden, Switzerland, Thailand, Turkey, and the United Kingdom.

Structural Characteristics (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Toremifene citrate is classified as a selective estrogen receptor modulator, with both agonist and antagonist properties. It has the chemical designation 2-{p-[(Z)-4-chloro-1,2-diphenyl-1-butenyl]phenoxy}-N,N-dimethylethylamine citrate (1:1).
Addendum: Why is Tamoxifen Carcinogenic? What Makes Toremifene Less Toxic? structural considerations and an explanation of toremifene’s decreased carcinogenicity.

Side Effects (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Toremifene citrate appears to be well tolerated, with a low incidence of serious side effects. In clinical trials, common side effects associated with its use included hot flashes (35%), sweating (20%), elevated liver enzymes (19%), nausea (14%), vaginal discharge (13%), dizziness (95%), edema (5%), vomiting (4%), and vaginal bleeding (2%). Other observed rare adverse events that may or may not be linked to toremifene citrate administration include low white blood cell and platelet counts, skin discoloration or dermatitis, constipation, difficulty breathing, partial motor paralysis, tremor, vertigo, itching, anorexia, visual disturbances, loss of strength, hair loss, depression, jaundice, and rigors (stiffening of the muscles). Antiestrogens may harm the developing fetus and should never be used during pregnancy.

Administration (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Toremifene citrate is FDA approved for the treatment of metastatic breast cancer in postmenopausal women with estrogen-receptor positive or unknown tumors. The recommended dose is one 60 mg tablet administered once per day. When used (off-label) to mitigate the estrogenic side effects of anabolic/androgenic steroid use, male athletes and bodybuilders may use 30 mg to 60 mg per day during steroid treatment.

Availability (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Toremifene citrate is widely available under the Fareston brand name. It is not commonly sold on the black market, nor is it a high-profile item for counterfeiters.
Last edited by Rick T on Mon Aug 28, 2023 5:50 pm, edited 1 time in total.
User avatar
Rick T
Posts: 135
Joined: Thu Jan 12, 2023 8:33 pm
Contact:

Re: Basicstero.ws - The Direct from Pharmacom Labs Store

Post by Rick T »

Addendum: structural considerations and an explanation of toremifene’s decreased carcinogenicity.

Why is Tamoxifen Carcinogenic? What Makes Toremifene Less Toxic?
Image

Most of these compounds may lead to long-term toxic effects. For instance, tamoxifen induces liver cancer in rats after prolonged administration, which has been attributed to the generation of DNA-alkylating species from the metabolism of the stilbene framework. It has been proposed that cytochrome P450 hydroxylates tamoxifen at the allylic position of the ethyl side chain, leading to an alcohol, which can generate a highly delocalized allylic cation 3.6 and therefore alkylate DNA to give product 3.7 through an SN1 mechanism (Fig. 3.6 below).
(Reference: Triphenylethylene - an overview | ScienceDirect Topics)

Image


This proposal also explains the lack of carcinogenicity of toremifene, which can be attributed to destabilization of the positive charge in 3.8 by the inductive effect of the chlorine substituent at the position adjacent to the allylic carbon (Fig. 3.7 below).
(Reference: Triphenylethylene - an overview | ScienceDirect Topics)

Image

Rick T wrote: Tue Aug 15, 2023 11:00 pm FARESTOS (Toremifene) – A More Modern SERM – is Available in the Basicstero Store.
Image

Toremifene (Fareston) is a more modern analogue of Tamoxifen and Clomid, which may be used to completely replace these older compounds’ useful properties.
Toremifene Citrate is a selective estrogen receptor modulator (SERM) derived from triphenylethylene. It was patented and approved in Europe in the mid 1990's to treat metastatic ER+ breast cancer in postmenopausal women.
Image
In bodybuilding toremifene citrate is used by men as a drug for post-cycle therapy (PCT) to counteract and/or block some of the effects of excessive estradiol in the body as a result of aromatization of various androgens used. In particular, toremifene is used to restore levels of endogenous testosterone in blood as well as to prevent the estrogen-related side effect of gynecomastia.
In its chemical structure toremifene is very similar to tamoxifen and clomiphene. However, toremifene is a new generation drug and has less toxic side effects than tamoxifen.
Toremifene dosage for a more effective boost in testosterone production should be in the range of up to 120mg per day. This dose can be maintained for a first week of PCT; then, 100mg/day for the second week of PCT; and, finally 60mg/day for the remaining 3 – 4 weeks of PCT. Of course, exact dosages should be determined individually based on blood work results.

This innovative SERM is currently available as a 50 count blister strip of 20 mg tablets at: basicstero.ws/pct/farestos-pills-20mg

Toremifene Information:
Image


Toremifene Description (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Toremifene citrate is an anti-estrogenic drug, specifically classified as a Selective Estrogen-Receptor Modulator (SERM) with mixed agonist and antagonist properties. It is a non-steroidal triphenylethylene derivative, similar in structure and action to both Nolvadex (tamoxifen citrate) and Clomid (clomiphene citrate). Toremifene citrate is used for the treatment of breast cancer in postmenopausal women with estrogen-receptor positive or estrogen-receptor unknown (unsure if the cancer is estrogen responsive) tumors. It works by attaching to the estrogen receptor in various tissues in a competitive manner, blocking endogenous estrogen from exerting biological activity. As an anti-estrogen in many tissues, male bodybuilders and athletes may use toremifene citrate to counter some of the side effects associated with the use of aromatizable or estrogenic anabolic/androgenic steroids. This may include gynecomastia, body fat gain, and increased water retention.

The triphenylethylene compounds (toremifene citrate, tamoxifen citrate, clomiphene citrate) tend to be somewhat intrinsically estrogenic in the liver. This means that while they can block estrogenic activity in some areas of the body, they can actually act as estrogens in this other key area. Estrogenic action in the liver is important in the regulation of serum cholesterol (it tends to support HDL synthesis and LDL reductions). Since steroid-using bodybuilders are already dealing with the negative cardiovascular effects of these drugs, compounding the issue with aromatase inhibitors (which will lower total serum estrogen levels) may not always be the best option. Using a drug that blocks gynecomastia, for example, while at the same time supporting improved cholesterol values, might be much more ideal. In terms of which triphenylethylene agent is most effective in this regard, evidence suggests that the positive lipid altering benefits of toremifene are significantly stronger than those of tamoxifen, a drug normally favored for this purpose. Toremifene citrate may, therefore, be the preferred antiestrogen among those concerned about their lipid profiles.

History (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Toremifene citrate was approved by the FDA as a prescription drug in 1997. It is sold in the U.S. under the Fareston brand name, which is made by GTx, Inc. Fareston is also available in over two dozen other countries including Australia, Austria, Belgium, Czech Republic, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Mexico, Netherlands, New Zealand, Portugal, Russia, South Africa, Spain, Sweden, Switzerland, Thailand, Turkey, and the United Kingdom.

Structural Characteristics (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Toremifene citrate is classified as a selective estrogen receptor modulator, with both agonist and antagonist properties. It has the chemical designation 2-{p-[(Z)-4-chloro-1,2-diphenyl-1-butenyl]phenoxy}-N,N-dimethylethylamine citrate (1:1).

Side Effects (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Toremifene citrate appears to be well tolerated, with a low incidence of serious side effects. In clinical trials, common side effects associated with its use included hot flashes (35%), sweating (20%), elevated liver enzymes (19%), nausea (14%), vaginal discharge (13%), dizziness (95%), edema (5%), vomiting (4%), and vaginal bleeding (2%). Other observed rare adverse events that may or may not be linked to toremifene citrate administration include low white blood cell and platelet counts, skin discoloration or dermatitis, constipation, difficulty breathing, partial motor paralysis, tremor, vertigo, itching, anorexia, visual disturbances, loss of strength, hair loss, depression, jaundice, and rigors (stiffening of the muscles). Antiestrogens may harm the developing fetus and should never be used during pregnancy.

Administration (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Toremifene citrate is FDA approved for the treatment of metastatic breast cancer in postmenopausal women with estrogen-receptor positive or unknown tumors. The recommended dose is one 60 mg tablet administered once per day. When used (off-label) to mitigate the estrogenic side effects of anabolic/androgenic steroid use, male athletes and bodybuilders may use 30 mg to 60 mg per day during steroid treatment.

Availability (credit: Llewellyn, William. “ANABOLICS” 11th ed. 2017.):
Toremifene citrate is widely available under the Fareston brand name. It is not commonly sold on the black market, nor is it a high-profile item for counterfeiters.
User avatar
Rick T
Posts: 135
Joined: Thu Jan 12, 2023 8:33 pm
Contact:

Re: Basicstero.ws - The Direct from Pharmacom Labs Store

Post by Rick T »

Basicstero's 2023 Powerful FALL PROMO is Active!
Image

Pay with cryptocurrency and get FREE bonuses as follows:
$100 of FREE bonus items for orders over $200.
$300 of FREE bonus items for orders over $500.
$600 of FREE bonus items for orders over $800.
$800 of FREE bonus items for orders over $1000.


Bonuses are picked during the ordering process and shipped together with the main order. No promo code is needed.
This promo is valid for orders from the International Warehouse (W1) only!
Please plan accordingly for international transit times.

In case of seizures/lost-packs only items that were paid for are reshipped, not free bonuses (please understand this means promo free bonus items are not included in a reship).
If you need discreet shipping please select the "Discreet Shipping" option during the check-out process on the "Address" page when you enter your order.
Pharmatropin GH is not participating in this promotion.
Nothing new with these terms and conditions - just the typical rules for many Basicstero promos.

Be sure to stay up-to-date with all the latest Promotions, News, and Announcements by checking the ”News” section on the Basicstero site (link below):
https://basicstero.ws/news

Make Fall a Powerful Season with Basicstero!
User avatar
Rick T
Posts: 135
Joined: Thu Jan 12, 2023 8:33 pm
Contact:

Re: Basicstero.ws - The Direct from Pharmacom Labs Store

Post by Rick T »

Here is Good News for guys that like to order from the Domestic Warehouse W2.

Basicstero has restocked the domestic warehouse (W2)!

Now you can find many popular items available in Warehouse W2 such as PharmaSust 300, PharmaTest C, and a lot of Enanthate.

Furthermore, Basicstero now has the well-loved Oxandrolonos in the Domestic Warehouse W2 as well.

Be sure to stay up-to-date with all the latest News and Announcements by checking the ”News” section on the Basicstero site.
User avatar
Rick T
Posts: 135
Joined: Thu Jan 12, 2023 8:33 pm
Contact:

Re: Basicstero.ws - The Direct from Pharmacom Labs Store

Post by Rick T »

Dear customers,

Basicstero would like to inform you that from September 27 to October 8, there will be extended holidays in Asia.
Therefore, the International Warehouse (W1) will not be able to process any shipments during this period.

Kindly be patient and thank you for your understanding!
User avatar
Rick T
Posts: 135
Joined: Thu Jan 12, 2023 8:33 pm
Contact:

Re: Basicstero.ws - The Direct from Pharmacom Labs Store

Post by Rick T »

Rick T wrote: Mon Sep 25, 2023 8:52 pm Dear customers,

Basicstero would like to inform you that from September 27 to October 8, there will be extended holidays in Asia.
Therefore, the International Warehouse (W1) will not be able to process any shipments during this period.

Kindly be patient and thank you for your understanding!
Hi everyone, the international warehouse is now back up and running - all orders placed during the holidays are now shipping!
User avatar
Rick T
Posts: 135
Joined: Thu Jan 12, 2023 8:33 pm
Contact:

Re: Basicstero.ws - The Direct from Pharmacom Labs Store

Post by Rick T »

Hi everyone, Basicstero has improved the website and added the "notifications" option. Now every customer will receive important site news directly in their dashboard!
Post Reply