an older thread but worth the read!!!!!!!!!!!!

Its so hard to find grape fruit juice here portugal, only one place and is always out stock for 4 euros 2 litres

MONSTRO wrote: ↑Tue Aug 25, 2020 3:33 pm Its so hard to find grape fruit juice here portugal, only one place and is always out stock for 4 euros 2 litres

Have you ever thought about buying grapefruit juice extract powder and using that?
Mind you many supplements tat are sold for body building in supplement shops have grapefruit juice extract powder extracts inside of their products just for this reason in the original post..

So what i ask is:
Can i use grape juice or orange juice to replace grapefruit juice ? or only real grape fruit juice increase the power of oral steroids?

MONSTRO wrote: ↑Thu Aug 27, 2020 10:11 pm So what i ask is:
Can i use grape juice or orange juice to replace grapefruit juice ? or only real grape fruit juice increase the power of oral steroids?

Only grapefruit juice or extracts because grapefruit binds to the intestinal isoenzyme, impairing first-pass metabolism directly and causing a sustained decrease in CYP3A4 protein expression.5 Within 4 hours of ingestion, a reduction in the effective CYP3A4 concentration occurs, with effects lasting up to 24 hours.6 The net result is inhibition of drug metabolism in the intestine and increased oral bioavailability.

So after all you said grapefruit juice is a must to increase the absortion of oral steroids. Now i see 4 euros per 2litres of juice is not expensive .

Vision do you know how much % absortion using grapefruit juice increase?

MONSTRO wrote: ↑Mon May 25, 2020 4:49 pm Here in my town i find this one is 4 euros 2 litres

that's the stuff right there..

it's almost the same price here believe it or not.. it's just slightly cheaper but not by much..
keep in mind you don't need much of it, and you need to take it everyday in order for it to work properly. it will not work just by one consumption. using it every day is when it works best.

500ml per day is enough? every day. I will go buy tomorow

Do you think is good to use intra workout? instead of gatorade? or best is take when you take the orals?

MONSTRO wrote: ↑Fri Aug 28, 2020 9:47 pm 500ml per day is enough? every day. I will go buy tomorow

Do you think is good to use intra workout? instead of gatorade? or best is take when you take the orals?

I would take it earlier in the day, 8-10oz is all you need, but it must be daily. I would take this 30min before orals. Let it knock out the enzymes and let it do this daily..

Hi all,
A really interesting topic, I’ve been researching to see what I can find out and found a study on grapefruit/drug interactions in which it said that there was no effect on Prednisolone, a glucocorticoid steroid.
I was wondering If anyone has experienced greater effects from using Grapefruit juice, and which steroids they were using? It might be worth gathering feedback to identify which compounds are affected most. Especially as I’ve read that some drugs/medication can be inhibited rather than enhanced! (Don’t want to waste the good stuff)
I was also wondering if anyone has had positive results with SARMS and grapefruit juice?

I have added the link to the study I found below:

https://nutritionj.biomedcentral.com/ar ... -2891-6-33

Cheers