Just found this linked to a study too:

Tamoxifen is metabolized by CYP2D6 into its active metabolite 4-hydroxytamoxifen. Grapefruit juice may potentially reduce the effectiveness of tamoxifen.

Beverage JN, Sissung TM, Sion AM, Danesi R, Figg WD (September 2007). "CYP2D6 polymorphisms and the impact on tamoxifen therapy". Journal of Pharmaceutical Sciences. 96 (9): 2224–31. doi:10.1002/jps.20892. PMID 17518364.

I have used 2 months ago with M1T and Anadrol and i can said i got bigger and can support 50mg M1T with 150mg anadrol for 4 weeks ( strong dosages ).
is suposed to increase absortion of oral steroids, but you have to understand is not a miricle increase that double power of orals .
Bodybuilding is a slow process , take time and humans dont have time to wait , they always looking for miricles like look like a top pro in 6 months.

Of course we all dream for it but is not possible , we have to keep focus and improve slowly day by day until reach your goals.

Lets GROW

I quite agree, there’s no point in taking substances if you’re not putting the time and effort in.
I’ve found a study that states CYP3A4 metabolises some SARMS, which suggests that grapefruit juice should have a positive impact inhibiting their breakdown too. To what extent I’m not sure, but if it helps to maximise their benefits it worth experimenting with.

“ CYP3A4 were implicated in metabolism of ostarine and LGD-4033 across species.”

https://pure.qub.ac.uk/en/studentTheses ... nd-in-vivo

I will keep using it and tastes great to.

Madmattward wrote: ↑Wed Sep 02, 2020 7:53 pm I quite agree, there’s no point in taking substances if you’re not putting the time and effort in.
I’ve found a study that states CYP3A4 metabolises some SARMS, which suggests that grapefruit juice should have a positive impact inhibiting their breakdown too. To what extent I’m not sure, but if it helps to maximise their benefits it worth experimenting with.

“ CYP3A4 were implicated in metabolism of ostarine and LGD-4033 across species.”

https://pure.qub.ac.uk/en/studentTheses ... nd-in-vivo

Great addition................. thank you for adding that!

This is the evolution of bodybuilding. Some people ask why bodybuilders grow over time and now they are huge if drugs are the same and in the 70´s all real pharmaceutical stuf, nutrition the same and training even more intense back then with basics. So why they are bigger now? KNOWLAGE . Now we know the best combination of drugs, foods and exercises . Now a bodybuilder needs to be smart and know about nutrition, training, drugs ( its a combination of nutricionist , personal trainer and doctor.


Information is POWER