Metformin, another AMPK activator, also stimulated myostatin expression at low concentrations. In addition, ectopic expression of AMPK wild-type α subunit (enhancing AMPK activity) and AMPK K45R mutant (knockdown AMPK activity) enhanced and reduced myostatin expression, respectively. These results indicate that AMPK stimulates myostatin expression in C2C12 cells, providing an explanation for the negative effect of AMPK on muscle growth.

Metformin enhanced myostatin mRNA expression…

Could be, but metformin lowers igf1.. If you try let us know.

Tren4life wrote: ↑Fri Jul 02, 2021 12:27 am Could be, but metformin lowers igf1.. If you try let us know.

Only issue and wrecks gut bacteria too

Why use something that can maybe block myostatin and same time reduce the powerful IGF . Very bad on gut and i have alot issues on my gut so why i will use it