Push50 wrote: ↑Tue Jun 20, 2023 8:21 pm Mesterolone (Proviron)


History: Currently produced by the pharmaceutical company Schering, Mesterolone was heavily researched in the 1970’s. For a brief period, it was evaluated for effectiveness as an anti-depressant, but with subsequent research showing Mesterolone to be less effective than newer treatment options, it is no longer considered an appropriate medication for this purpose. Although rare, Mesterolone is sometimes prescribed as a treatment for men suffering from low libido.
In many ways, Proviron is a unique anabolic steroid. It shares some strong similarities to Masteron (Drostanolone) and to a degree Anavar (Oxandrolone) and Winstrol (Stanozolol) but it has its own distinctive qualities. In a performance capacity, Proviron is not used to promote large buildups in mass, although it can be used during the bulking phase, you will generally find it being used far more commonly in cutting cycles.
As a therapeutic agent, Proviron is one of the most used anabolic steroids in modern medicine. However, the Mesterolone hormone has never been approved by the U.S. FDA. It will primarily be found in European medicine, especially in Western Europe. The primary purpose of use is treating androgen deficiencies, age being the most common culprit of the condition. It is, however, also used in pre-pubescent males as well. The hormone is also used as a fertility aid in men, and this alone makes it a very unique anabolic steroid as most anabolic steroids tend to have the opposite effect.
Mesterolone is a dihydrotestosterone (DHT) derived anabolic androgenic steroid. Specifically, it is a structurally altered DHT hormone with the addition of a methyl group at the carbon one position. This allows the hormone to survive oral ingestion by protecting it from hepatic breakdown. This is one of the only oral anabolic steroids that is not C17-alpha alkylated (C17-aa) but instead carries the added methyl group, like oral primobolan.
Proviron also can interact with the aromatase enzyme, the enzyme responsible for the conversion of testosterone to estrogen. By binding to the aromatase enzyme, Proviron can actually inhibit aromatase activity, thereby offering protection against estrogenic side effects. It will not carry an anti-estrogenic effect near the level of power of an Aromatase Inhibitor (AI) but it will be notable. Depending on the nature of the cycle the individual undertakes it is quite possible for Proviron to take care of all your anti-estrogen needs.
The Mesterolone hormone will also carry a strong binding affinity to the androgen receptor. Once again this will promote the functionality of other steroids to a degree but more importantly promote enhanced metabolic activity through direct lipolysis.
This is an anabolic steroid that does not suppress gonadotropins similarly to other anabolic steroids. With minimal suppression and its extremely strong androgenicity, this will enhance sperm production as androgens are necessary to spermatogenesis stimulation. Not only will Proviron enhance the amount of sperm produced but greatly and equally important is the quality of the sperm.

Method of Administration: Mesterolone is administered in oral form.
Steroid Class: Mesterolone is a DHT derivative, belonging to the DHT-family of steroids.
Primary Use: Unlike nearly every other steroid, Proviron is not used for muscle-building. In fact, the drug displays almost no anabolic activity at all. Despite this shortcoming, Mesterolone has retained its popularity due to the unique qualities it possesses. There are 3 primary uses for which this drug is best suited, which are: 1) Its ability to reduce circulating estrogen. 2) Its exceptional SHBG binding affinity. 3) Its ability to increase libido. Mesterolone reduces circulating estrogen by exhibiting a stronger binding affinity for the aromatase enzyme comparative to testosterone. This directly decreases the amount of aromatase enzyme testosterone has to interact with, thereby decreasing testosterone’s estrogen conversion rate. This reduced estrogen level can have several different effects on the user, such as the prevention of estrogen mediated side effects, to cosmetic enhancements like reduced water retention and increased muscle hardness. Proviron is also frequently used to help maximize the muscle-building potential of one’s cycle by indirectly increasing the level of free testosterone/AAS available to muscle tissue, which it accomplishes by reducing levels of sex hormone binding globulin. Last but not least, Proviron is regularly used for libido enhancement, with many considering it to be the single most effective treatment option for this purpose.
Anabolic-Androgenic Ratio: 30:100
Aromatizable: No. Exhibits anti-estrogenic activity.
Progestagenic Activity: No.
Methylated: Yes. Methylation serves as a protective feature of most oral AAS, allowing the molecule the pass through the liver and enter the bloodstream intact, after which it can travel to muscle tissue and exert its muscle-building effects.
Standard Dosing Range and Cycle Length: Mesterolone is commonly dosed at 25-100 mg per day for a period of 6-16 weeks.
Frequency of Administration: Daily use; Split into 2 equally divided doses.