So, is there some real truth to fat loss and AAS..Below is some info I did my best to put together, along with some studies... The reality is you will not get peeled and cut like a great God just from using AAS expecting to loss weight, it will assist, however getting peeled down is commitment and dedication to diet and training..
Now, many times over the years there's been a massive debates, out right internet hissy fights in regards to AAS and fat loss..Some in the gear world populace are advocating that there's "no such thing", or AAS don't burn fat.. While others who see the picture understand that it has properties and know the major differences.. Fat-loss vs getting ripped it 2 different things when it concerns this topic..
Let's dig in deep here and see what we have.. let's discuss this AAS only, no stims or bata's,or GH, just AAS (steroids)
Now, you're gonna hear mix reviews on this.. However, I have seen enough evidence that supports AAS having,creating a environment/platform for fat burning..DIET without a doubt is crucial, and the pivotal player..However, there is real science behind fat loss and AAS, but please don't put all your money on it solely as an effective combatant..But nonetheless AAS is effective!
As many of us should know "nutrient partitioning" is one of many parts and mechanisms, its a cascade of events with nutrients being shuttled is a huge factor in which effects are taking place..
But lets talk about what AAS can do, the possibilities, and the capabilities that are astonishing the medical research field and athletes worldwide..
Truth is; Science knows more about the cosmos than they do with hormones, we're merely scratching the service and there's always newer data/clinical studies out-dating an others contradicting each other and so on, but its only getting better and more advanced with actually explanations if you dig deep enough and care to understand.. One Dr my cite this, as an other cites that, just know what how to decipher what you're hearing/reading and research your research.
AAS that are seen/recognized on the high/or moderate androgenic scale will in fact promote/increase lypolysis..Thus andros have a higher binding affinity to AR's..
FYI; Androgen receptors are found throughout cellular groups, as well as FAT and muscle cell/groups, now we know that they initiate a response on AR's in muscle cells to promote size/growth, at the same given time they will have a cascade of effects on other cells and AR's found therein fat cells inducing activity/burning..
Higher/more potent the androgen binds to the androgen receptors, the greater the lipolytic response will be on adipose tissue (brown or white)...
Now lets also take into great consideration AR upregulation with the presence of androgens, more AR sites throughout targeting tissue..,There's a vast amount of activity in which a complex interplay between activation and inactivation mechanisms and signaling between cell groups, what People need to remember that hormones are "chemical messengers" that rely messages to cells that display specific receptors for each hormone and respond to the signaling..Depending on the compounds and the individuals metabolization ratio the hormone can/may make changes directly to a cell, by changing the genes that are activated, or by making changes indirectly to a cell by stimulating other signaling pathways inside a specific cell group that is effected and effect other processes, thus this can "initiate" an intracellular cascade of events.. So, the notion that fat Loss is NOT presence, and to mitigate that AAS don't posses any fat loss properties is absurd...
So, yes AAS may assist with fat loss, however don't expect miracles and it's advised to have a lower body fat% by diet to expect to see more fat loss effects, but its not crucial..Have your macro's dialed in with your AAS intake, cardio ,and anything is possible, we've seen amazing things happen in this lifestyle..Even a couch potato can see results (whether it's deserving or not is a completely different topic)
There's an abundance of clinical research and peer-reviewed data that strongly supports testosterone (and other AAS) fat reducing actions and its preventative impact on adipocyte generation...As AAS (especially Testosterone) acts both in the breakdown of existing fat tissue and to hinder pre-adipocytes from maturing.
This is where some AAS began you acquire there reputation, or spin a myth (winstrol & Anavar) at promoting fat loss, and achieve lower body fat,cuts..With this said, there's some truth behind winstrol & Anavar achieving cuts cuts, but not directly more as a indirect effect!
Medical study: twelve weeks on oxandrolone
A study done at the University of Southern California in 2004. The researchers gave thirty men over sixty a daily dose of 20 mg of oxandrolone for twelve weeks and observed what happened. After reading the study you might wonder whether giving androgens to people who don't work out is such a good idea.
Relatively safe
Oxandrolone is perhaps the safest oral anabolic steroid ever to make its way on to the market. One of the reasons for this is because it doesn't metabolise easily.Study
The researchers wanted to know whether you can use male hormones to counter the decline in muscle mass and power that sets in with aging. For their experiments they selected thirty healthy men over the age of sixty, and gave them the dose that doctors advise for 'undesired weight loss due to unknown causes'. Twenty got oxandrolone, ten got a placebo. The researchers gave them a course of twelve weeks of taking the steroid, and examined the men again twelve weeks after the course had finished. The men did no weight training.
Results
The muscle measurements of those who had taken oxandrolone grew considerably. The figure below shows the thigh muscle cross-sectional area.
As you can see, after twelve weeks the men had more muscle bulk. How much of this was left after the men had been clean for twelve weeks the researchers didn't measure, but going by the figure below it wasn't much. This figure shows the change in the lean body mass. Lean body mass also includes muscle mass.
Most of the lean body mass built up during the course of oxandrolone had disappeared after twelve weeks.
Oxandrolone has a similar effect on muscle power. Twelve weeks of oxandrolone increased the weight the men could shift on the leg press, the lat pulley, the leg extension and the chest press in the lab. But twelve weeks after stopping with the oxandrolone the extra strength had all but disappeared again.
The effects of oxandrolone on the fat mass were more lasting. The fat mass decreased considerably in the first twelve weeks, and the effect could still be seen twelve weeks later.
The course of oxandrolone did not pose health risks. The researchers monitored the men's liver enzymes, cholesterol, LH and the prostate cancer marker PSA, but noticed nothing alarming.
The men did not do weight training. Many chemical athletes notice that stopping with training after finishing a course of steroids results in loss of the muscle mass gained. Maybe the men would have benefited more from the oxandrolone if they had trained as well.
When steroids are taken, the body's own production of testosterone declines. Therefore chemical athletes often use other substances to help boost their endogenous hormone production. This is referred to as post cycle therapy (PCT). The test subjects in this study did not do this either.
Sources:
J Appl Physiol. 2004 Mar;96(3):1055-62.
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Below is some studies conducted in fat loss, one in particular stresses the relation with diet and TRT and others just on a placebo and diet...The outcome is astonishing, just about all AAS to a degree like i.e Var/winny wcan and will share the same effects with fat loss as testosterone!!
Testosterone Treatment Combined With Diet Reduces Fat, Maintains Muscle
April 5, 2016
By Frances Morin
BOSTON -- April 5, 2016 -- Obese men treated with testosterone in addition to a low-calorie diet show greater reduction in body fat and less loss of muscle mass than men on similar diets who did not receive testosterone, according to a study presented here at the 98th Annual Meeting of the Endocrine Society (ENDO).
“In men successfully losing weight through diet, both lean and fat mass are lost,” said Mark Ng Tang Fui, MBBS, BMedSc, The University of Melbourne, Heidelberg, Australia, on April 3.
“The addition of testosterone prevents the loss of lean mass and shifts weight loss to almost exclusive loss of fat,” he added.
Obesity has been linked to lower testosterone levels, whereas weight loss resulting from calorie restriction is linked to increases in circulating testosterone, noted the researchers. At the same time, weight loss in middle-aged men typically depletes fat and muscle.
Although testosterone treatment has been also shown to reduce fat mass, the effects of combining testosterone treatment with calorie restriction have not been demonstrated.
For the study, the researchers enrolled 100 obese men (body mass index [BMI], >30 kg/m2), aged 18 to 75 years, with low to low-normal serum total testosterone levels (average of 2 consecutive morning fasting levels of <12 nmol/L [<346 ng/dL]).
The men were all placed on a very-low-calorie diet (~600 kcal/day) for 10 weeks, followed by a maintenance period of 46 weeks. They were randomised 1:1 in a blinded fashion to receive intramuscular testosterone 1,000 mg or placebo injections at baseline, week 6, and every 6 weeks thereafter over the 56 weeks of the study.
At the study’s end, weight loss in both groups was similar, ie, an average of 11 kg (24.2 lb; P < .05 vs baseline). However, patients in the testosterone group lost 3 kg (6.6 lb) more body fat than those in the placebo group (P = .05) and lost significantly less lean mass than those in the placebo group (P = .001).
Patients in the testosterone group also lost significantly more visceral adipose tissue at week 56 (P < .05).
“We found that testosterone treatment reduces fat mass in obese men with a low testosterone level, more than the effects of diet alone,” concluded Dr. Fui. “Testosterone treatment also reduces visceral fat, more than the effects of diet alone, and prevents diet-associated loss of lean mass and muscle function.”
“Although these changes are expected to be metabolically favourable, further trials in this population need to determine cardiometabolic and other benefits weighed against potential adverse effects,” Dr. Fui added.
[Presentation title: Effect of Testosterone Therapy Combined With a Very Low Caloric Diet on Fat Mass in Obese Men With a Low to Low-Normal Testosterone Level: A Randomized Controlled Trial. Abstract LB-OR02-1]
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Testosterone therapy in hypogonadal men results in sustained and clinically meaningful weight loss
Abstract
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:
Hypogonadism is associated with increased fat mass and reduced muscle mass, which contributes to obesity and health risks, such as cardiovascular disease.Testosterone treatment of hypogonadal men improves muscle mass and reduces fat mass; however, many of these studies are of short duration.Thus, the long-term effects of testosterone on body anthropometry are not known.
WHAT THIS STUDY ADDS:
Long-term testosterone treatment of hypogonadal men, up to 5 years duration, produced marked and significant decrease in body weight, waist circumference and body mass index. Hypogonadism contributes to reduced muscle mass and increased adiposity.Testosterone treatment ameliorates loss of muscle mass and reduces fat accumulation associated with hypogonadism. In this study, we evaluated the long-term effects of normalizing testosterone (T) levels in hypogonadal men on anthropometric parameters. Open-label, single-center, cumulative, prospective registry study of 261 men (32-84 years, mean 59.5 ± 8.4 years, with T levels ***8804;12 nmol L-1 [mean: 7.7 ± 2.1]). Among the 261 men on T treatment, we followed up on 260 men for at least 2 years, 237 for 3 years, 195 for 4 years and 163 for at least 5 years. Subjects received parenteral T undecanoate 1000 mg every 12 weeks after an initial interval of 6 weeks. Body weight (BW), waist circumference (WC) and body mass index (BMI) were measured at baseline and yearly after treatment with T. BW decreased from 100.1 ± 14.0 kg to 92.5 ± 11.2 kg and WC was reduced from 107.7 ± 10.0 cm to 99.0 ± 9.1 cm. BMI declined from 31.7 ± 4.4 m kg-2 to 29.4 ± 3.4 m kg-2. All parameters examined were statistically significant vs. baseline and vs. the previous year over 5 years, indicating a continuous weight loss (WL) over the full observation period. The mean per cent WL was 3.2 ± 0.3% after 1 year, 5.6 ± 0.3%, after 2 years, 7.5 ± 0.3% after 3 years, 9.1 ± 0.3% after 4 years and 10.5 ± 0.4% after 5 years. The data obtained from this uncontrolled, observational, registry study suggest that raising serum T to normal physiological levels in hypogonadal men produces consistent loss in BW, WC and BMI. These marked improvements were progressive over the 5 years of the study.
