I wanna touch base on serms and ai's. What they are and how they work..


The term SERM stands for Selective Estrogen Receptor Modulator, and AI's , stand for Aromatase inhibitor.


SERM's compete for the space that Estrogen binds to(receptors). When this occurs, the receptor is then full and hence blocks out the estrogen. Here are some SERM's .
Tamoxifen (Nolvadex)

Clomiphene Citrate (Clomid),


Toremifene Citrate (Fareston),

Raloxifene hydrochloride (Evista).



Nolva is Commonly dosed at 10-40 mgs. It has a high affinity for binding to breast tissue receptors. It can significantly raise Testosterone levels. However, it can reduce IGF-1 levels. Something to keep in mind. It will reduce the blood levels of Arimidex and Letro by up to 40% rendering them less effective. It does not affect Aromasin.

Clomid: Usually dosed from 25-150 mgs during pct for support of natural Testosterone levels
Clomid acts as both an agonist/ antagonist -- Clomid is an effective antagonist in the hypothalamus and in breast tissue. It is an effective agonist in bone tissue, and for improving blood cholesterol.

It should also be noted that Clomid has an estrogenic effects on mood,be ready to cry watching your favorite commercial.


Evista: Evista is a second-generation SERM. It is approved by the FDA for this use in women. Although it has structural and mechanistic similarities to other SERMs which have been approved either as fertility drugs (Clomid) or Breast Cancer medication (Nolvadex), it has not been approved for either of those uses. Ralixofene exerts its effects by antagonizing the estrogen receptor in some tissues, and agonizing it in others. In this way, certain estrogenic pathways are activated and others are blocked. It seems to exert estrogenic effects on blood lipids, reducing LDL and total cholesterol, as well as estrogenic effects on bone.


Toremifene: Usually dosed around 60 mg. Its androgenicity:estrogenicity ratio is 5x that of Nolvadex. It is prescribed to female patients for breast cancer and has shown a high affinity for binding to the Estrogen receptors in breast tissue. Male patients treated with toremifene citrate 80 mg compared to placebo demonstrated statistically significant increases in bone mineral density in the lumbar spine, hip, and femur skeletal sites. . Toremifene citrate 80 mg treatment compared to placebo also resulted in a decrease in total cholesterol, LDL, and triglycerides, and an increase in HDL. There were also statistically significant improvements in gynecomastia. This data is from an ongoing study of men receiving treatment for ADT (androgen depravation therapy). These men are receiving ADT for advanced prostate cancer. ADT removes much of the testosterone and estrogen in the body which helps the prostatic cancer cells grow.. Some studies have even suggested that Toremifene doesn't regulate progesterone receptors and we may see in the future the possibility of using it with 19-nors.



Some possible side effects include the risk of stroke, pulmonary embolism, and cataracts.


A typical post cycle therapy (pct) of Toremifene would look similar to this:
Week 1: 120mg ED
Week 2: 90mg ED
Week 3: 60mg ED
Week 4: 30mg ED
Toremifene is by far my favorite serm. Its to bad more people dont care it.


Aromatase inhibitors:
AIs are categorized into two types:


Type 1: steroidal inhibitors such as exemestane/aromasin form a permanent or irreversible bond with the aromatase enzyme
Type 2: inhibitors (such as anastrozole, letrozole) inhibit the enzyme by reversible competition.


AI's work by inhibiting the action of the enzyme aromatase, which converts androgens into estrogens by a process called aromatization. By inhibiting aromatase they increase Testosterone and reduce Gynecomastia.


1. Letrozole ( Femara) is a type 2


Letro: Letrozole has been shown to reduce estrogen levels by 98% or more.Administration of Letrozole lowered Estrogen by 46% in the young men tested, and 62% in the elderly subjects. Because estrogen is part of the negative feedback loop of the HPTA, Letrozole (and other anti-estrogens) are able to raise testosterone in male subjects. Letrozole was found to significantly increase LH levels to a 339% and 323% in the young and the elderly, respectively and Testosterone by 146 and 99%, respectively.
Letro has a 2-4 day half life
Normal dosing is .25 - 2.5mg ed

Arimidex type 2:

Arimidex: seems to be the most popular aromatase inhibitor of choice. Usually doesed from 0.25 - 1.0mg eod it is effective even when not used every day. 0.5mgs per day can get rid of up to 50% estrogen.


AROMASIN type 1: Exemestane (Aromasin)



History: Initially researched as a treatment option for breast cancer in the late 90’s, Aromasin was demonstrated to be superior to Tamoxifen and was subsequently released by Pfizer. A fairly recent addition to the anti-estrogen marketplace.
Aromasin is usally doesed from 20-50 mgs per day. It can raise blood testosterone by 60%, and also help out your free to bound testosterone ratio by lowering levels of Sex Hormone Binding Globulin (SHBG), by about 20%! It can suppress estrogen by 65-80%

Method of Administration: Aromasin is administered in oral form.
Drug Class: Suicidal Aromatase Inhibitor.


Primary Use: Aromasin, like all anti-estrogens, is used to help normalize/maintain estrogen levels within the body. Aside from the prevention of estrogenic side effects, estrogen management can assist users in maintaining a hard & dry appearance when using aromatizable drugs. This is especially useful prior to a contest, when displaying this looks is essential to success. Aromasin accomplishes this function by binding with the aromatase enzyme, which is responsible for converting testosterone (and other aromatizable drugs) into estrogens. Once bound, Aromasin will permanently deactivate the aromatase enzyme, preventing any further interaction and eliminating the possibility of experiencing estrogen rebound. This ability to permanently deactivate the aromatase enzyme is what classifies Aromasin as a suicide inhibitor, as not all anti-estrogens have this effect. This advantage is one of the key differences between Aromasin and several other anti-estrogens. However, Aromasin needs to be dosed frequently in order to maintain adequate blood levels of the drug; preferably twice per day, or every 12 hours. This is in significant contrast to several other AI’s, which only need to be dosed every few days. Additionally, unlike all other AI’s, which have been shown to potentially have a negative impact on cholesterol levels, Aromasin is neutral in this regard, making it the more heart health alternative.


Anabolic-Androgenic Ratio: N/A.
Aromatizable: No. Exhibits anti-estrogenic activity.
Progestagenic Activity: No.
Methylated: No.


Standard Dosing Range and Cycle Length: Aromasin is commonly administered at a dosage of 12.5-50 mg per day. Dosing requirements will be determined by the number, type, and amount of aromatizable drugs being used. The drug is typically administered as long as aromatizable drugs are present.


Frequency of Administration: Daily usage; split into 2 equally divided doses.

Remember when comparing ai 's

2.5mg of letro = 1mg adex = 25mg araomasin.

During the off season cycle try not to use, focus on proviron and masteron first. If you fell sore nipples, maybe tamoxifen 20mg take care off , and probably the best option during bulking ( it hinders only the estrogen in breat area leaving the estrogen in body to grow)
Pre contest exemestano until 2 weeks out and then letro last 2 weeks , the best to get shreded and hard.

Arimidex is to weak in heavy compounds on bulking and to weak pre contest to.

Jozifp103 wrote: ↑Tue Jun 09, 2020 12:00 pm Awesome awesome awesome write up.

I've had experience with almost all of these compounds and here's my take:

Nolva - Does its job as far as recovery. Decent recovery aid by itself, works much better with Clomid. No real side effects, pretty smooth run. Nothing really noteworthy to speak of.

Clomid - Also decent recovery aid but works better with Nolva. Mental side effects for me were almost unbearable. I was crying over ex girlfriends that I haven't seen in 6 years. Crying in the car when a sad song comes on, crying at movies and even fucking commercials. Shit really turned me into a woman lol.

Toremifene - Fantastic PCT/recovery tool. Works as good, if not better than Nolva and Clomid combined for HPTA recovery. Virtually side effect free. Made PCT a breeze for me.

Ralozifene - No actual experience but I know it's the best SERM for gyno hands down. It binds so strongly to the estrogen receptors, especially in the breast that gyno doesn't stand a chance even if estrogen is highly elevated.

Arimidex - Tried and true AI. Used to be my go-to until I tried Aromasin. Adex did have a negative effect on my lipids and you really have to monitor your blood because if you are taking a dose that's even slightly too high or too low your E2 will slowly creep in either direction and eventually either crash or elevate to the point of side effects.

Aromasin - My new go-to AI. The feel-good AI. It definitely made me feel better than Arimidex, and it doesn't skew my lipids like Adex does. Also Aromasin is more forgiving so you can get away with dosing a little higher without crashing your E2. I will say that Arimidex works better for high dosed cycles or compounds that Aromatize heavily. Aromasin can't seem to keep up with heavy aromatization. But for most peoples' needs it's perfect.

Letro - Never needed it. Tried it once while on Trestolone because I wanted to drop some water weight but it turns out I didn't really need it and I didn't like the way it made me feel so I went back to Arimidex. But Letro is great for people who aromatize heavily, are prone to gyno, or are running sure heavy cycles with compounds that aromatize heavily.

That's my personal take. It seems your descriptions were spot on with my experience. Nice work bro.

Thanks and right back at ya with your description and experience.. I would absolutely love to see toremifene!!! I know many would also. I personally love the stuff when I compare to tamox. Nothing against tamox but I felt way better and recovery seemed like instant... Even when on cycle instead of tamox in a pinch I needed something and torem worked fast and my balls were gynormous. Lol. You wouldn't of thought you were on cycle.

Tamox in the more used and is in market for many years so is tested and works , and off course is cheap . I use during bulking cycle to control my estrogen on gland and keep other estrogen in to grow more .

Hey, folks -

If I understand correctly, my 5000iu HCG will be coming in a 2mL vial and be powder/crystal. Is it preferable to use Bacteriostatic Water over Acetic Acid Solution when mixing? Also, would storing at room temperature be adequate? I'm specifically talking about Eurigil5000 iu/amp PG.

Much appreciated!