HCG during cycle

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HCG During Cycle
HCG in combination with Nolvadex can and should be used during prolonged (12+/wks) and high dosage (1,000+mgs/wk) cycles. In this case, 500-1,000 IUs HCG ED in combination with 20 mgs Nolvadex ED for 7-10 days consecutively is administered mid cycle or intermittently (every 6-8 weeks) during the cycle.

Maintaining testicular volume during cycle does in fact improve recovery when compared to atrophied testes when beginning PCT. This solution addresses both testicular atrophy and prevention of Leydig cell desensitization (discussed next) associated with HCG usage.


Leydig Cell Desensitization
Leydig cell desensitization does in fact occur to some degree with prolonged or high dose HCG usage. Using it continuously during a cycle could possibly cause the LH receptor to desensitize which in turn would ultimately render the PCT to be either less effective or possibly useless. This seems counterproductive. HCG will not be needed on cycles where the proper ancillaries are used and where the dosages/durations are realistic.

The previous summary was a general statement. The reality and good news is that Leydig cell desensitization due to HCG usage is blocked and/or minimized by Nolvadex. This occurs by suppressing HCG’s ability to inhibit the conversion of 17 alpha hydroxyprogesterone to testosterone.

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