At the same time others claiming one ester to be superior to its counterparts..
These particular instances are all individual based on each own static system of checks & loops, respectively, there's no 2 individuals that are a carbon copy..
This is why people argue that Cypionate is much more potent than Enanthate, or vise versa
as this is a fragile argument at best and is absurd. Your receptors are only recognizing free bi-hormone no matter what the ester that was utilized to deploy the parenting hormone!
Let's launch this topic with the expression "single hormones yielding an opposite effect rather than a positive response to the hormone as some individuals claim/experience"..
An appropriate analogy to kick-off with would be to look at an alcoholic as an example...
Why and alcoholic?
Genetics..now worries, I'll explain!
Everyone posses different gene expression,with enzymes,protein bonds,and so on..
(Enzymes are known to catalyze more then 5k biochemical types)..
Yet our bodies posses inhibitors and activator molecules that can greatly effect the activity,
by increasing or decreasing hormonal actives..
Now, that of an acholohic,it's a genetic predisposition (same applies for particular endocrines with sensitive users concerning AAS) in which one posses a group of particular enzymes that metabolize alcohol much differently compared to other individuals,
thus the effects will be much greater, and more detrimental in some individuals over the next..(Different metabolization)
Now, let's equate this with hormones..
( Starting Example would be) Testosterone..
Testosterone may play 3 roles..
1) Testosterone as its primary function..
2) At times converting into DHT (dihydrotestosterone: a more potent androgen)
3) And the one that nobody likes - Converting into estrogen :o
Here you see this effect stands-out greatly by individual instances because genetics, age or even ethnicity in some cases,
and at times even sex may be a factor, whether one has a greater presence of aromatase enzymes, or even a deficiency..
Hormones have various biosynthetic pathways that is scribed in the endorcrine,
some of these scribed pathways are either at the end of there pathway or before reaching their target tissue receptor (to control plasma levels or active compounds),
and at times after termination of their actions inactivation and elimination..
However many of hormones and esters are metabolized within their target tissue,
in which a complex interplay between activation and inactivation mechanisms serve to regulate the specificity and the amplitude of the hormonal response..
Bear in mind that this is why a "singular ester" or any hormones in HRT/TRT treatment is by no means designed as a one size fits all therapy...
For your reference: There's two main types of enzymes that act in the cleaving process of the ester in which activate the hormone...
These 2 particular "Enzymes" are esterases & hydrolysate. These come along and cleave pieces of the ester off the hormone,
thereby releasing the active chemical (parenting steroid hormone) and allowing it to do its job (ultimately muscle building/tissue via protein synthesis, positive nitrogen balance and so on )...
Now in the bloodstream which testosterone and blood born nutrients and substances circulate is recognized as the "medium".
These enzymes circulate in the medium and directly affect the release of active hormone in the bloodstream by ester cleavage, thus exerting different expression per individuals, trigger a chute of cellular interaction at receptor sites that will differ from one to the next.
People need to remember that hormones are "chemical messengers" that rely messages to cells that display specific receptors for each hormone and respond to the signaling..Depending on the ester and the individuals metabolization ratio the hormone can/may make changes directly to a cell, by changing the genes that are activated, or by making changes indirectly to a cell by stimulating other signaling pathways inside a specific cell group that is effected and effect other processes, thus this can initiate an intracellular cascade of events..
This is why the same singular hormone ester effects some people differently, there's numerous ways a hormone can project different effects.. Depending on which transcription factors are present different genes will be transcribed in response...Consequently, the reason some individuals tend to bloat and others do NOT, as some can run 250mgs of testosterone and begin to see systems of fluid retention or edema exert in the circular system or particular regions of the body with estrogen.. At the same time there's individuals that can use 1000mgs of of testosterone and remain completely dry..
Naturally we know that diet is permitted and will be a huge reflection.. However, this article's about biosynthesis, not diet...
Regards,
Vision
